The N348I Mutation at the Connection Subdomain of HIV-1 Reverse Transcriptase Decreases Binding to Nevirapine

The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase (RT) confers clinically significant resistance to both nucleoside and non-nucleoside RT inhibitors (NNRTIs) by mechanisms that are not well understood. We used transient kinetics to characterize the enzymatic properties of...

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Détails bibliographiques
Auteurs principaux: Schuckmann, Matthew M., Marchand, Bruno, Hachiya, Atsuko, Kodama, Eiichi N., Kirby, Karen A., Singh, Kamalendra, Sarafianos, Stefan G.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Enzymology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992303/
https://ncbi.nlm.nih.gov/pubmed/20876531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153783
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