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Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR
Drug-metabolizing enzymes (DMEs) and transporters play pivotal roles in the disposition and detoxification of numerous foreign and endogenous chemicals. To accommodate chemical challenges, the expression of many DMEs and transporters is up-regulated by a group of ligand-activated transcription facto...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2991607/ https://ncbi.nlm.nih.gov/pubmed/20727377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2010.08.006 |
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