MITOCHONDRIAL OXIDANT STRESS INCREASES PDE5 ACTIVITY IN PERSISTENT PULMONARY HYPERTENSION OF THE NEWBORN

In the pulmonary vasculature, phosphodiesterase-5 (PDE5) degrades cGMP and inhibits nitric oxide-mediated, cGMP-dependent vasorelaxation. We previously reported that ventilation with 100% O(2) increased PDE5 activity in pulmonary arteries (PA) of pulmonary hypertension lambs (PPHN) more than in cont...

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Main Authors: Farrow, Kathryn N., Wedgwood, Stephen, Lee, Keng Jin, Czech, Lyubov, Gugino, Sylvia F., Lakshminrusimha, Satyan, Schumacker, Paul T., Steinhorn, Robin H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991478/
https://ncbi.nlm.nih.gov/pubmed/20804862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2010.08.018
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