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Increased p22(phox)/Nox4 Expression Is Involved in Remodeling Through Hydrogen Peroxide Signaling in Experimental Persistent Pulmonary Hypertension of the Newborn

Aim: To determine if the NADPH oxidase isoform Nox4 contributes to increased H(2)O(2) generation in persistent pulmonary hypertension of the newborn (PPHN) pulmonary arteries (PA), and to identify downstream signaling targets of Nox4 that contribute to vascular remodeling and vasoconstriction. Resul...

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Detalhes bibliográficos
Main Authors: Wedgwood, Stephen, Lakshminrusimha, Satyan, Czech, Lyubov, Schumacker, Paul T., Steinhorn, Robin H.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619152/
https://ncbi.nlm.nih.gov/pubmed/23244636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4766
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