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Structural Determinants of Inhibitor Selectivity in Prokaryotic IMP Dehydrogenases
The protozoan parasite Cryptosporidium parvum is a major cause of gastrointestinal disease; no effective drug therapy exists to treat this infection. Curiously, C. parvum IMPDH (CpIMPDH) is most closely related to prokaryotic IMPDHs, suggesting that the parasite obtained its IMPDH gene via horizonta...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2991053/ https://ncbi.nlm.nih.gov/pubmed/21035731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.07.014 |
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