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Formation of Deoxyguanosine Cross-links from Calf Thymus DNA Treated with Acrolein and 4-Hydroxy-2-nonenal
Acrolein (AC) and 4-hydroxy-2-nonenal (HNE) are α,β-unsaturated aldehyde (enal) endogenous bis-electrophiles that arise from the oxidation of polyunsaturated fatty acids. AC is also found in high concentrations in cigarette smoke and automobile exhaust. These reactive enals covalently modify nucleic...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2990652/ https://ncbi.nlm.nih.gov/pubmed/20964440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx100179g |
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