Activity of irinotecan and temozolomide in the presence of O(6)-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models

BACKGROUND: The combination of temozolomide (TMZ) and irinotecan is a regimen used in neuroblastoma patients with recurrent disease. O(6)-methylguanine-DNA methyltransferase (MGMT) may have a function in resistance to TMZ. Using neuroblastoma pre-clinical models, we determined whether the inhibition...

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Hlavní autoři: Cai, W, Maldonado, N V, Cui, W, Harutyunyan, N, Ji, L, Sposto, R, Reynolds, C P, Keshelava, N
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990610/
https://ncbi.nlm.nih.gov/pubmed/20924375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605927
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