Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease

The copy number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie susceptibility to inflammatory disorders, but presents considerable challenges for accurate typing on the scale required for adequately powered case–control studies. In this work, we have used accura...

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Detalhes bibliográficos
Main Authors: Aldhous, Marian C., Abu Bakar, Suhaili, Prescott, Natalie J., Palla, Raquel, Soo, Kimberley, Mansfield, John C., Mathew, Christopher G., Satsangi, Jack, Armour, John A.L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989891/
https://ncbi.nlm.nih.gov/pubmed/20858604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq411
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