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The structural basis for catalysis and substrate specificity of a rhomboid protease

Rhomboids are intramembrane proteases that use a catalytic dyad of serine and histidine for proteolysis. They are conserved in both prokaryotes and eukaryotes and regulate cellular processes as diverse as intercellular signalling, parasitic invasion of host cells, and mitochondrial morphology. Their...

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Bibliografische gegevens
Hoofdauteurs: Vinothkumar, Kutti R, Strisovsky, Kvido, Andreeva, Antonina, Christova, Yonka, Verhelst, Steven, Freeman, Matthew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989101/
https://ncbi.nlm.nih.gov/pubmed/20890268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.243
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