Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells

HIV-1 replication in simian cells is restricted at an early postentry step because of the presence of an inhibitory cellular factor. This block reduces the usefulness of HIV-1-based lentiviral vectors in primate animal models. Here, we demonstrate that substitution of the cyclophilin A (CyPA) bindin...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Kootstra, Neeltje A., Münk, Carsten, Tonnu, Nina, Landau, Nathaniel R., Verma, Inder M.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298767/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12547912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0337541100
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