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Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells

HIV-1 replication in simian cells is restricted at an early postentry step because of the presence of an inhibitory cellular factor. This block reduces the usefulness of HIV-1-based lentiviral vectors in primate animal models. Here, we demonstrate that substitution of the cyclophilin A (CyPA) bindin...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kootstra, Neeltje A., Münk, Carsten, Tonnu, Nina, Landau, Nathaniel R., Verma, Inder M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298767/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12547912/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0337541100
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