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Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells
HIV-1 replication in simian cells is restricted at an early postentry step because of the presence of an inhibitory cellular factor. This block reduces the usefulness of HIV-1-based lentiviral vectors in primate animal models. Here, we demonstrate that substitution of the cyclophilin A (CyPA) bindin...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The National Academy of Sciences
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC298767/ https://ncbi.nlm.nih.gov/pubmed/12547912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0337541100 |
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