Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells
HIV-1 replication in simian cells is restricted at an early postentry step because of the presence of an inhibitory cellular factor. This block reduces the usefulness of HIV-1-based lentiviral vectors in primate animal models. Here, we demonstrate that substitution of the cyclophilin A (CyPA) bindin...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2003
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298767/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12547912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0337541100 |
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