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Human RORγt(+) T(H)17 cells preferentially differentiate from naive FOXP3(+)Treg in the presence of lineage-specific polarizing factors
RORγt(+) T(H)17 cells are a proinflammatory CD4(+) T-cell population associated with autoimmune tissue injury. In mice, priming of T(H)17 requires TGF-β, which alone directs the priming of FOXP3(+) regulatory T cells (Treg), in association with inflammatory cytokines. Priming of human T(H)17 cells f...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2984184/ https://ncbi.nlm.nih.gov/pubmed/20962281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008247107 |
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