Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes.

We have designed an Ha-ras/thymidine kinase (TK) cassette that permits the incorporation of chemically synthesized adducts within specific domains of the rat Ha-ras protooncogene. This cassette has been used to evaluate the mutagenicity of O6-substituted guanine residues, including O6-methylguanine...

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Bibliografiske detaljer
Main Authors: Mitra, G, Pauly, G T, Kumar, R, Pei, G K, Hughes, S H, Moschel, R C, Barbacid, M
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC298345/
https://ncbi.nlm.nih.gov/pubmed/2682655
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