Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes.

We have designed an Ha-ras/thymidine kinase (TK) cassette that permits the incorporation of chemically synthesized adducts within specific domains of the rat Ha-ras protooncogene. This cassette has been used to evaluate the mutagenicity of O6-substituted guanine residues, including O6-methylguanine...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mitra, G, Pauly, G T, Kumar, R, Pei, G K, Hughes, S H, Moschel, R C, Barbacid, M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298345/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2682655/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.22.8650
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