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Mechanisms of double-strand break repair in somatic mammalian cells

DNA chromosomal DSBs (double-strand breaks) are potentially hazardous DNA lesions, and their accurate repair is essential for the successful maintenance and propagation of genetic information. Two major pathways have evolved to repair DSBs: HR (homologous recombination) and NHEJ (non-homologous end-...

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Detalles Bibliográficos
Main Authors: Hartlerode, Andrea J., Scully, Ralph
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2983087/
https://ncbi.nlm.nih.gov/pubmed/19772495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090942
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