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Activation of the Pacidamycin PacL Adenylation Domain by MbtH-Like Proteins

Nonribosomal peptide synthetase (NRPS) assembly lines are major avenues for the biosynthesis of a vast array of peptidyl natural products. Several hundred bacterial NRPS gene clusters contain a small (~70 residue) protein belonging to the MbtH family for which no function has been defined. Here we s...

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Detalhes bibliográficos
Main Authors: Zhang, Wenjun, Heemstra, John R., Walsh, Christopher T., Imker, Heidi J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982891/
https://ncbi.nlm.nih.gov/pubmed/20964365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101539b
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