Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics.

The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. Oxygen and active oxygen-radical scavengers have no significant influence upon DNA strand breakage by esperamicin. The preferential cutting sites of esperamicin are at thymidylate residues, and the frequenc...

Description complète

Détails bibliographiques

Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Sugiura, Y, Uesawa, Y, Takahashi, Y, Kuwahara, J, Golik, J, Doyle, T W
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2813351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.20.7672
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!