Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics.

The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. Oxygen and active oxygen-radical scavengers have no significant influence upon DNA strand breakage by esperamicin. The preferential cutting sites of esperamicin are at thymidylate residues, and the frequenc...

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Bibliographic Details
Main Authors: Sugiura, Y, Uesawa, Y, Takahashi, Y, Kuwahara, J, Golik, J, Doyle, T W
Format: Artigo
Language:Inglês
Published: 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC298132/
https://ncbi.nlm.nih.gov/pubmed/2813351
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