Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics.
The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. Oxygen and active oxygen-radical scavengers have no significant influence upon DNA strand breakage by esperamicin. The preferential cutting sites of esperamicin are at thymidylate residues, and the frequenc...
Guardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1989
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2813351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.20.7672 |
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