Binding of a hairpin polyamide in the minor groove of DNA: sequence-specific enthalpic discrimination.

Hairpin polyamides are synthetic ligands for sequence-specific recognition in the minor groove of double-helical DNA. A thermodynamic characterization of the DNA-binding properties exhibited by a six-ring hairpin polyamide, ImPyPy-gamma-PyPyPy-beta-Dp (where Im = imidazole, Py = pyrrole, gamma = gam...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pilch, D S, Poklar, N, Gelfand, C A, Law, S M, Breslauer, K J, Baird, E E, Dervan, P B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38666/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710866/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8306
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