Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics.

The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. Oxygen and active oxygen-radical scavengers have no significant influence upon DNA strand breakage by esperamicin. The preferential cutting sites of esperamicin are at thymidylate residues, and the frequenc...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Sugiura, Y, Uesawa, Y, Takahashi, Y, Kuwahara, J, Golik, J, Doyle, T W
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1989
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2813351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.20.7672
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