A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.

The introduction of human immunoglobulin gene segments in their unrearranged configuration into the germ line of mice might allow the production of a repertoire of human antibodies. Such transgenic mice could be used for the production of human monoclonal antibodies against human antigens. To test t...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Brüggemann, M, Caskey, H M, Teale, C, Waldmann, H, Williams, G T, Surani, M A, Neuberger, M S
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2505258/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.17.6709
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