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Production of Protective Human Antipneumococcal Antibodies by Transgenic Mice with Human Immunoglobulin Loci

Infections with Streptococcus pneumoniae remain a significant cause of morbidity and mortality. To gain insight into structure-function relationships for human antibodies to pneumococcal capsular polysaccharide (PPS), we studied the response of transgenic mice reconstituted with human immunoglobulin...

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Autori principali: Russell, Nina D., Corvalan, Jose R. F., Gallo, Michael L., Davis, C. Geoffrey, Pirofski, Liise-anne
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC97353/
https://ncbi.nlm.nih.gov/pubmed/10722569
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