A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.

The introduction of human immunoglobulin gene segments in their unrearranged configuration into the germ line of mice might allow the production of a repertoire of human antibodies. Such transgenic mice could be used for the production of human monoclonal antibodies against human antigens. To test t...

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Bibliographic Details
Main Authors: Brüggemann, M, Caskey, H M, Teale, C, Waldmann, H, Williams, G T, Surani, M A, Neuberger, M S
Format: Artigo
Language:Inglês
Published: 1989
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC297915/
https://ncbi.nlm.nih.gov/pubmed/2505258
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