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Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line.

From a hybrid mouse cell line (B1-8) that secreted an IgM, lambda 1 anti-(4-hydroxy-3-nitrophenyl)acetyl antibody but that had no detectable surface IgM, selection for a variant with lambda 1 chains on the surface resulted in the isolation of a line that had switched from mu to delta expression. The...

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Detalhes bibliográficos
Main Authors: Neuberger, M S, Rajewsky, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1981
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC319962/
https://ncbi.nlm.nih.gov/pubmed/6940132
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