A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.

The introduction of human immunoglobulin gene segments in their unrearranged configuration into the germ line of mice might allow the production of a repertoire of human antibodies. Such transgenic mice could be used for the production of human monoclonal antibodies against human antigens. To test t...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Brüggemann, M, Caskey, H M, Teale, C, Waldmann, H, Williams, G T, Surani, M A, Neuberger, M S
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1989
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2505258/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.17.6709
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