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Inhibition of Short Patch and Long Patch Base Excision Repair by an Oxidized Abasic Site
5′-(2-Phosphoryl-1,4-dioxobutane) (DOB) is an oxidized abasic lesion that is produced by a variety of DNA damaging agents, including several antitumor antibiotics. DOB efficiently, and irreversibly inhibits DNA polymerase β, an essential base excision repair enzyme in mammalian cells. The generality...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2976803/ https://ncbi.nlm.nih.gov/pubmed/20961055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101533a |
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