The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1

BACKGROUND: Heat shock protein 90 (HSP90) inhibitors have emerged as a promising class of anti-cancer drugs in both solid and hematologic malignancies. The HSP90 family includes the cytosolic HSP90 (HSP90AA1), the ER paralogue gp96 (HSP90B1) and the mitochondrial member TRAP1 (HSP90L). We evaluated...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Usmani, Saad Z, Bona, Robert D, Chiosis, Gabriela, Li, Zihai
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974653/
https://ncbi.nlm.nih.gov/pubmed/20977755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-3-40
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki