The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1

BACKGROUND: Heat shock protein 90 (HSP90) inhibitors have emerged as a promising class of anti-cancer drugs in both solid and hematologic malignancies. The HSP90 family includes the cytosolic HSP90 (HSP90AA1), the ER paralogue gp96 (HSP90B1) and the mitochondrial member TRAP1 (HSP90L). We evaluated...

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Hauptverfasser: Usmani, Saad Z, Bona, Robert D, Chiosis, Gabriela, Li, Zihai
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974653/
https://ncbi.nlm.nih.gov/pubmed/20977755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-3-40
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