Effects of Synaptic Modulation on β-Amyloid, Synaptophysin, and Memory Performance in Alzheimer's Disease Transgenic Mice

Accumulation of β-amyloid (Aβ) and loss of synapses are hallmarks of Alzheimer's disease (AD). How synaptic activity relates to Aβ accumulation and loss of synapses is a current topic of major interest. Synaptic activation promotes Aβ secretion, and chronic reduction of synaptic activity reduce...

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Main Authors: Tampellini, Davide, Capetillo-Zarate, Estibaliz, Dumont, Magali, Huang, Zhenyong, Yu, Fangmin, Lin, Michael T., Gouras, Gunnar K.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2010
Assuntos:
Brief Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972675/
https://ncbi.nlm.nih.gov/pubmed/20980585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3383-10.2010
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