Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia

INTRODUCTION: Autophagy enables cells to recycle long-lived proteins or damaged organelles. Beclin 1, the mammalian orthologue of the yeast Apg6/Vps30 gene, functions as a scaffold for the formation of autophagosomes. MATERIALS AND METHOD: The immunohistochemical patterns of Beclin 1 expression and...

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Main Authors: Koukourakis, M I, Giatromanolaki, A, Sivridis, E, Pitiakoudis, M, Gatter, K C, Harris, A L
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2010
主題:
Molecular Diagnostics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967071/
https://ncbi.nlm.nih.gov/pubmed/20842118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605904
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