PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

Here we describe the expression and function of a HIF-1-regulated protein pyruvate dehydrogenase kinase-1 (PDK-1) in head and neck squamous cancer (HNSCC). Using RNAi to downregulate hypoxia-inducible PDK-1, we found that lactate and pyruvate excretion after 16–48 h of hypoxia was suppressed to norm...

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Main Authors: Wigfield, S M, Winter, S C, Giatromanolaki, A, Taylor, J, Koukourakis, M L, Harris, A L
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2008
主題:
Molecular Diagnostics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441961/
https://ncbi.nlm.nih.gov/pubmed/18542064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604356
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