PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

Here we describe the expression and function of a HIF-1-regulated protein pyruvate dehydrogenase kinase-1 (PDK-1) in head and neck squamous cancer (HNSCC). Using RNAi to downregulate hypoxia-inducible PDK-1, we found that lactate and pyruvate excretion after 16–48 h of hypoxia was suppressed to norm...

Fuld beskrivelse

Na minha lista:

Bibliografiske detaljer
Main Authors:	Wigfield, S M, Winter, S C, Giatromanolaki, A, Taylor, J, Koukourakis, M L, Harris, A L
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2008
Fag:	Molecular Diagnostics
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2441961/ https://ncbi.nlm.nih.gov/pubmed/18542064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604356
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

Lignende værker