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PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
Here we describe the expression and function of a HIF-1-regulated protein pyruvate dehydrogenase kinase-1 (PDK-1) in head and neck squamous cancer (HNSCC). Using RNAi to downregulate hypoxia-inducible PDK-1, we found that lactate and pyruvate excretion after 16–48 h of hypoxia was suppressed to norm...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2441961/ https://ncbi.nlm.nih.gov/pubmed/18542064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604356 |
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