Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis

Lactate dehydrogenase-5 (LDH-5) catalyses the reversible transformation of pyruvate to lactate, having a principal position in the anaerobic cellular metabolism. Induction of LDH-5 occurs during hypoxia and LDH-5 transcription is directly regulated by the hypoxia-inducible factor 1 (HIF1). Serum LDH...

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Главные авторы: Koukourakis, M I, Giatromanolaki, A, Sivridis, E, Bougioukas, G, Didilis, V, Gatter, K C, Harris, A L
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2003
Предметы:
Molecular and Cellular Pathology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394471/
https://ncbi.nlm.nih.gov/pubmed/12942121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601205
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