Neuroserpin Protects Neurons from Ischemia-Induced Plasmin-Mediated Cell Death Independently of Tissue-Type Plasminogen Activator Inhibition

The serine proteinase tissue-type plasminogen activator (tPA) and the serine proteinase inhibitor neuroserpin are both expressed in areas of the brain with the highest vulnerability to hypoxia/ischemia. In vitro studies show that neuroserpin inhibits tPA and, to a lesser extent, urokinase-type plasm...

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Autori principali: Wu, Jialing, Echeverry, Ramiro, Guzman, Johanna, Yepes, Manuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2010
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966813/
https://ncbi.nlm.nih.gov/pubmed/20864675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100466
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