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Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus

The best-known function of the serine protease tissue-type plasminogen activator (tPA) is as a thrombolytic enzyme. However, it is also found in structures of the brain that are highly vulnerable to hypoxia-induced cell death, where its association with neuronal survival is poorly understood. Here,...

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Detalhes bibliográficos
Main Authors: Echeverry, Ramiro, Wu, Jialing, Haile, Woldeab B., Guzman, Johanna, Yepes, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877952/
https://ncbi.nlm.nih.gov/pubmed/20440070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41722
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