Tissue-type Plasminogen Activator Protects Neurons from Excitotoxin-induced Cell Death via Activation of the ERK ½ -CREB-ATF3 Signaling Pathway

The release of the serine proteinase tissue-type plasminogen activator (tPA) from cerebral cortical neurons has a neuroprotective effect in the ischemic brain. Because excitotoxicity is a basic mechanism of ischemia-induced cell death here we investigated the effect of tPA on excitotoxin-induced neu...

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Bibliographic Details
Main Authors: Wu, Fang, Echeverry, Ramiro, Wu, Jialing, An, Jie, Haile, Woldeab B., Cooper, Deborah S., Catano, Marcela, Yepes, Manuel
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540185/
https://ncbi.nlm.nih.gov/pubmed/23063501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2012.10.001
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