CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer’s Disease Mouse Models

Microglia, the primary immune effector cells in the brain, continually monitor the tissue parenchyma for pathological alterations and become activated in Alzheimer’s disease. Loss of signaling between neurons and microglia via deletion of the microglial receptor, CX3CR1, worsens phenotypes in variou...

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Detalhes bibliográficos
Main Authors: Lee, Sungho, Varvel, Nicholas H., Konerth, Megan E., Xu, Guixiang, Cardona, Astrid E., Ransohoff, Richard M., Lamb, Bruce T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966811/
https://ncbi.nlm.nih.gov/pubmed/20864679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100265
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