CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer’s Disease Mouse Models

Microglia, the primary immune effector cells in the brain, continually monitor the tissue parenchyma for pathological alterations and become activated in Alzheimer’s disease. Loss of signaling between neurons and microglia via deletion of the microglial receptor, CX3CR1, worsens phenotypes in variou...

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Bibliografiske detaljer
Main Authors: Lee, Sungho, Varvel, Nicholas H., Konerth, Megan E., Xu, Guixiang, Cardona, Astrid E., Ransohoff, Richard M., Lamb, Bruce T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966811/
https://ncbi.nlm.nih.gov/pubmed/20864679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100265
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