Oligodendrocyte PTEN required for myelin and axonal integrity not remyelination

OBJECTIVE: Repair of myelin injury in multiple sclerosis may fail resulting in chronic demyelination, axonal loss and disease progression. As cellular pathways regulated by Phosphatase and tensin homologue deleted on chromosome 10 (PTEN; e.g., PI-3Kinase) have been reported to enhance axon regenerat...

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Auteurs principaux: Harrington, Emily P., Zhao, Chao, Fancy, Stephen P.J., Kaing, Sovann, Franklin, Robin J.M., Rowitch, David H.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966537/
https://ncbi.nlm.nih.gov/pubmed/20853437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22090
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