Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of oligodendrocyte precursors (OLPs) blocked at a pre...

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Autores principales: Fancy, Stephen P.J., Baranzini, Sergio E., Zhao, Chao, Yuk, Dong-In, Irvine, Karen-Amanda, Kaing, Sovann, Sanai, Nader, Franklin, Robin J.M., Rowitch, David H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2009
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704469/
https://ncbi.nlm.nih.gov/pubmed/19515974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1806309
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