Immunohistochemical detection of ZAP70 in chronic lymphocytic leukemia predicts immunoglobulin heavy chain gene mutation status and time to progression

Zeta-associated protein-70 (ZAP70) expression measured by flow cytometry has been proposed as a surrogate marker of the somatic mutation status of the immunoglobulin heavy chain variable region genes in chronic lymphocytic leukemia. However, attempts to implement this approach in clinical flow cytom...

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Main Authors: Admirand, Joan H., Knoblock, Ronald J., Coombes, Kevin R., Tam, Constantine, Schlette, Ellen J., Keating, Michael J., Luthra, Rajyalakshmi, Medeiros, L. Jeffrey, Abruzzo, Lynne V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966512/
https://ncbi.nlm.nih.gov/pubmed/20657554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2010.131
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