Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR

BACKGROUND: To determine the mechanisms associated with loss of androgen dependency and disease progression in prostate cancer (PCa), we investigated the relationship between the androgen receptor (AR) and mTOR pathways and the impact of inhibiting both pathways in androgen-dependent and castration-...

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Bibliografiske detaljer
Main Authors: Schayowitz, A, Sabnis, G, Goloubeva, O, Njar, V C O, Brodie, A M H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965879/
https://ncbi.nlm.nih.gov/pubmed/20842117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605882
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