Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

In a screen for RNA mutagen resistance, we isolated a high fidelity RNA dependent RNA polymerase (RdRp) variant of Coxsackie virus B3 (CVB3). Curiously, this variant A372V is also resistant to amiloride. We hypothesize that amiloride has a previously undescribed mutagenic activity. Indeed, amiloride...

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Hlavní autoři: Levi, Laura I., Gnädig, Nina F., Beaucourt, Stéphanie, McPherson, Malia J., Baron, Bruno, Arnold, Jamie J., Vignuzzi, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965762/
https://ncbi.nlm.nih.gov/pubmed/21060812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001163
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