Heparanase regulates retention and proliferation of primitive Sca-1(+)/c-Kit(+)/Lin(−) cells via modulation of the bone marrow microenvironment

Heparanase is involved in tumor growth and metastasis. Because of its unique cleavage of heparan sulfate, which binds cytokines, chemokines and proteases, we hypothesized that heparanase is also involved in regulation of early stages of hematopoiesis. We report reduced numbers of maturing leukocytes...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Spiegel, Asaf, Zcharia, Eyal, Vagima, Yaron, Itkin, Tomer, Kalinkovich, Alexander, Dar, Ayelet, Kollet, Orit, Netzer, Neta, Golan, Karin, Shafat, Itay, Ilan, Neta, Nagler, Arnon, Vlodavsky, Israel, Lapidot, Tsvee
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Hematology 2008
נושאים:
Hematopoiesis and Stem Cells
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964260/
https://ncbi.nlm.nih.gov/pubmed/18334674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-116145
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