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Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation

Heparanase is an endo-β-glucuronidase that specifically cleaves the saccharide chains of heparan sulfate proteoglycans. Heparanase plays important roles in processes such as angiogenesis, tumor metastasis, tissue repair and remodeling, inflammation and autoimmunity. Genetic variations of the heparan...

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Hlavní autoři: Ostrovsky, Olga, Korostishevsky, Michael, Shafat, Itay, Mayorov, Margarita, Ilan, Neta, Vlodavsky, Israel, Nagler, Arnon
Médium: Artigo
Jazyk:Inglês
Vydáno: The Society for Leukocyte Biology 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796676/
https://ncbi.nlm.nih.gov/pubmed/19406828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1208735
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