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Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis
Heparanase is an endoglycosidase that degrades heparan sulfate (HS) at the cell surface and in the extracellular matrix. Heparanase is expressed mainly by cancer cells, and its expression is correlated with increased tumor aggressiveness, metastasis, and angiogenesis. Here, we report the cloning of...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650141/ https://ncbi.nlm.nih.gov/pubmed/19164514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812846106 |
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