Heparanase regulates retention and proliferation of primitive Sca-1(+)/c-Kit(+)/Lin(−) cells via modulation of the bone marrow microenvironment

Heparanase is involved in tumor growth and metastasis. Because of its unique cleavage of heparan sulfate, which binds cytokines, chemokines and proteases, we hypothesized that heparanase is also involved in regulation of early stages of hematopoiesis. We report reduced numbers of maturing leukocytes...

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Bibliografiske detaljer
Main Authors: Spiegel, Asaf, Zcharia, Eyal, Vagima, Yaron, Itkin, Tomer, Kalinkovich, Alexander, Dar, Ayelet, Kollet, Orit, Netzer, Neta, Golan, Karin, Shafat, Itay, Ilan, Neta, Nagler, Arnon, Vlodavsky, Israel, Lapidot, Tsvee
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964260/
https://ncbi.nlm.nih.gov/pubmed/18334674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-116145
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