Heparanase regulates retention and proliferation of primitive Sca-1(+)/c-Kit(+)/Lin(−) cells via modulation of the bone marrow microenvironment

Heparanase is involved in tumor growth and metastasis. Because of its unique cleavage of heparan sulfate, which binds cytokines, chemokines and proteases, we hypothesized that heparanase is also involved in regulation of early stages of hematopoiesis. We report reduced numbers of maturing leukocytes...

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Detalhes bibliográficos
Main Authors: Spiegel, Asaf, Zcharia, Eyal, Vagima, Yaron, Itkin, Tomer, Kalinkovich, Alexander, Dar, Ayelet, Kollet, Orit, Netzer, Neta, Golan, Karin, Shafat, Itay, Ilan, Neta, Nagler, Arnon, Vlodavsky, Israel, Lapidot, Tsvee
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964260/
https://ncbi.nlm.nih.gov/pubmed/18334674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-116145
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