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Robustness and evolvability in the functional anatomy of a PER-ARNT-SIM (PAS) domain
The robustness of proteins against point mutations implies that only a small subset of residues determines functional properties. We test this prediction using photoactive yellow protein (PYP), a 125-residue prototype of the PER-ARNT-SIM (PAS) domain superfamily of signaling proteins. PAS domains ar...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964196/ https://ncbi.nlm.nih.gov/pubmed/20889915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004823107 |
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