Robustness and evolvability in the functional anatomy of a PER-ARNT-SIM (PAS) domain

The robustness of proteins against point mutations implies that only a small subset of residues determines functional properties. We test this prediction using photoactive yellow protein (PYP), a 125-residue prototype of the PER-ARNT-SIM (PAS) domain superfamily of signaling proteins. PAS domains ar...

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Bibliographische Detailangaben
Hauptverfasser: Philip, Andrew F., Kumauchi, Masato, Hoff, Wouter D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964196/
https://ncbi.nlm.nih.gov/pubmed/20889915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004823107
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